News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Leroy Hood’s Institute for Systems Biology Joining Forces with Providence Health & Services in a Partnership Aimed at Advancing Scientific Wellness

Hood predicts US healthcare spending will drop in the coming years as genome sequencing becomes routine for hospital patients and big data leads to advancements in disease prevention

Systems biology is a field of scientific research that has the potential to provide plenty of new biomarkers that could be used by clinical laboratories to detect disease earlier and with more accuracy and to guide physicians on how to treat disease. Now comes news of a unique collaboration designed to use knowledge of systems biology in ways that can advance clinical care.

The Institute for Systems Biology (ISB) recently teamed up with Providence Health & Services (Providence) to advance the mission of ISB’s President and co-founder Leroy Hood, MD, PhD, to transform healthcare through “Scientific Wellness.”

Pathologists and clinical laboratory managers will want to note this new partnership. That’s because ISB’s end-goal is the pre-symptomatic diagnosis of disease using multiplex assays to pinpoint protein biomarkers that signal the presence of disease. (more…)

In 2017, to Offset Declining Reimbursement and Shrinking Budgets, Savvy Clinical Laboratories Are Using LEAN to Improve Service and Intelligently Cut Costs

Nation’s most experienced lab operations managers, cost-cutters, and Lean experts will gather to share successes and proven ideas at Lab Quality Confab on October 18-19, 2016

Most hospitals and health systems are in the first stages of developing their budgets for 2017. Clinical laboratory administrators and pathologists at these institutions report three common factors are driving the next budget cycle: falling reimbursement, flat or declining inpatient admissions, and directives to cut their lab budgets.

“At our health system, the challenge is a bit different,” said one lab administrator at a large Midwest hospital. “Inpatient volumes are increasing, but we get less money from health insurers per admission. For that reason, our budget planning requirement is to accept a smaller budget than last year, while planning to handle more specimen volume in 2017, compared to this year.” (more…)

Paper-Strip Medical Laboratory Test Under Development at Ohio State University Promises to Bring Low-Cost Malaria Tests to Resource-Strapped Nations

Clinical laboratory assays based on low-cost paper strip tests could make detecting malaria easier in rural areas of Africa and Southeast Asia

In the field of remote medical pathology, diagnostic tests strips made from paper can provide low-cost, simple-to-perform testing in developing nations. These are regions where such diagnostic test capabilities are desperately needed by medical laboratory scientists and resource-strapped clinical laboratories.

One such example is a new paper strip test that can detect malaria for people in rural areas of Africa and southeast Asia. Such tests could also lower the cost of diagnostic testing in other parts of the world. Research teams have been working on various paper-based tests for at least the last decade. (more…)

Lab-on-a-Chip Diagnostics: When Will Clinical Laboratories See the Revolution?

Offering lower costs and quicker returns than much of the traditional lab equipment in use today, lab-on-a-chip devices are again in a position to revolutionize pathology and medical laboratory work

For nearly 20 years, researchers have heralded microfluidic devices, paper-based diagnostics, and other lab-on-a-chip (LOC) technologies, as ways for medical laboratory scientists, pathologists, and other medical diagnostic professionals to reduce the time and costs of clinical laboratory services. With the promise of obtaining results in just minutes without the need for extensive training, these point-of-care tests and devices create big buzz with each new design.

An yet, after all that progress, most laboratories still depend on their spectrometers, flow cytometers, blood analyzers, and other equipment for the bulk of their testing and routines.

That leaves one major question for clinical laboratory professionals and chip developers alike—when is the revolution? (more…)

Genetic Testing and Counseling Now Offered to Amway Employees Through a New Interleukin Test for Periodontal Disease called PerioPredict

Companies are exploring creative ways to use genetic testing and counseling to improve the health of their employees demonstrating increasing trust in genetic science

Genetic testing has been a product offered by distributors of Amway Global of Ada, Mich., since 2009. Now Amway is launching a program to provide certain genetic tests to its employees working within the United States.

More than 5,000 Amway employees can take advantage of this genetic testing as an innovative benefit. Through its partnership with Interleukin Genetics (NYSE Amex: ILI), a genetics-based health company headquartered in Waltham, Mass., Amway seeks to empower its personnel to assess their genetic risk for chronic inflammation, which can lead to disease. (more…)

New Fast, Inexpensive, Mobile Device Accurately Identifies Healthcare-Acquired Infections and Communicates Findings to Doctors’ Smartphones and Portable Computers

Use of these new technologies creates opportunities for clinical laboratories and pathologists to add more value when collaborating with physicians to advance patient care

Ongoing improvements in point-of-care testing are encouraging one major academic medical center to apply this mode of testing to the diagnosis of hospital-acquired infections (HAIs). This development should be of interest to clinical laboratory professionals and pathologists, since it has the potential to create a different way to identify patients with HAIs than medical lab tests done in the central laboratory.

Massachusetts General Hospital (MGH), Harvard Medical School’s (HMS’) largest teaching hospital, has developed a prototype diagnostic system that works with doctors’ smartphones or mobile computers. The hand-held system can identify pathogens responsible for specific healthcare-acquired infections (HAIs) at the point of care within two hours, according to an MGH statement.

The researchers noted that 600,000 patients develop HAIs each year, 10% of which die, and that costs related to HAIs can reach $100 to $150 billion per year. However, as Dark Daily reported, the Centers for Medicare and Medicaid Services (CMS) does not reimburse hospitals for certain HAIs. (See Dark Daily, Consumer Reports Ranks Smaller and Non-Teaching Hospitals Highest in Infection Prevention,” October, 30, 2015.) Thus, the critical need to identify from where the infection originated, which generates a significant proportion of samples tested at the clinical laboratories of the nation’s hospitals and health systems.

Therefore, pathologists and medical laboratory scientists will understand that shifting some of that specimen volume to point-of-care testing will change the overall economics of hospital laboratories.

Smartphone-based Genetic Test for HIAs

The MGH research team created a way to do accurate genetic testing in a simple device powered by a system they call Polarization Anisotropy Diagnostics (PAD). The system measures changes in fluorescence anisotropy through a detection probe’s recognition of bacterial nucleic acid, reported Medscape Medical News. More than 35 probes for detecting bacterial species and virulence factors are available.

Optical test cubes are placed on an electronic base station that transmits data to a smartphone or computer, where results are displayed. “In a pilot clinical test, PAD accuracy was comparable to that of bacterial culture. In contrast to the culture, the PAD assay was fast (under two hours), multiplexed, and cost effective (under $2 per assay), wrote the MGH researchers in the journal Science Advances. (more…)

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