News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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New studies in UK and at Stanford University Show Lung Cancer Cells Circulating in Blood; Findings Could Make it Possible for Pathologists to Diagnose Cancer with ‘Liquid Biopsies’

Researchers at two different universities find circulating tumor cells in blood specimens and suggest that CTCs might be incorporated into medical laboratory tests for detecting cancer

One goal of many research initiatives is to develop a clinical laboratory test which can detect circulating tumor cells (CTC) in blood. This would be a less invasive method for testing and it is hoped such a test could detect cancer at a much earlier stage, when treatment can be much more successful.

Much effort is being put into developing what pathologists call a “liquid biopsy.” Recently, researchers at The University of Manchester in the United Kingdom (UK) and at Stanford University in the United States each published articles in Nature Medicine offering compelling data about the role blood tests could play in the diagnosis and treatment of lung cancer. (more…)

Collaboration of Caltech Engineers and LeukoDX Produces Prototype Point-of-Care Device That Counts White Blood Cells in Minutes in the Patient’s Home

The science behind the device is an innovative detection assay of dyes that stain leukocytes so they will fluoresce and enable differentiation of white blood cell subtypes 

Over the last couple of years, medical laboratory technology developers have brought a number of FDA-approved point-of-care (POCT) and home self-tests to market.

These medical tests run the full spectrum. They include tests to detect HIV, malaria, pregnancy or male fertility, drug use or Hepatitis C. There are tests to monitor liver function, glucose in diabetics, cholesterol; and provide needle-free CBCs and genetic tests. (more…)

British Teen Builds DNA Testing Analyzer in His Bedroom, Wins Award as UK Young Engineer of 2013

PCR testing moves out of the clinical pathology laboratory and into a teen-aged boy’s bedroom laboratory

In a demonstration of how evolving technologies make it easier and cheaper to operate clinical laboratories, a teen-age boy in Yorkshire, England, has built his own DNA analyzer and identified the gene mutation that gives his brother red hair.

That demonstration allowed Fred Turner, age 17, to silence the endless teasing from friends about how he and his red-haired brother, Gus, probably had different fathers. It also won for Fred the award of “UK Young Engineer of the Year 2013.” (more…)

Duke University Researchers Demonstrate that Non-invasive Optical Biopsy Detects Cancer

New technology could reduce or even eliminate the need for clinical pathology laboratories to utilize tissue biopsies in the diagnosis of certain cancers

“Cancer flashlight” is the nickname some have given to a system that uses novel spectroscopic techniques to detect pre-cancerous cells in the colon. Developed by bioengineers at Duke University, the device may offer an alternative to current biopsy methods for detecting cancer and pre-cancer by anatomic pathologists.

The new technology may be a way to detect abnormal, dysplastic cells in the epithelium of various tissues in a non-invasive way, wrote The Atlantic in a story it recently published. The Atlantic thinks this technology breakthrough may be significant because approximately 85% of all cancers begin within the layers of the epithelium in various parts of the body.
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UK’s Association for Clinical Biochemistry Calls for Better Blood-draw Training for ED Doctors

Studies show clinical laboratories still grapple with sub-optimal specimens from emergency departments and better phlebotomy skills are part of the solution

Improving the quality of medical laboratory specimens collected by the staff of emergency departments is an ongoing goal at most American hospitals. Now everyone associated with phlebotomy will be interested in a study released in the United Kingdom (UK) that recommends that emergency department doctors in that country would benefit from a refresher course on correct specimen collection technique.

Clinical laboratory managers and phlebotomists in most developed nations are well acquainted with the problem of faulty specimens sent from the emergency department. That is the problem highlighted by this UK study. (more…)

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