May 24, 2013 | Digital Pathology, Instruments & Equipment, Laboratory Instruments & Laboratory Equipment, Laboratory News, Laboratory Operations, Laboratory Pathology
New discoveries demonstrate important advantages of whole-genome sequencing in investigations of DNA ‘dark matter’ and shed light on the possible origins of cancer
Whole-genome scanning of cancer cells revealed significant mutations in the “dark matter” areas of melanoma DNA. This represents a leap forward in the basic science of cancer. Easier access to whole-genome sequencing means that researchers are poised to mine a rich vein of data that will shine a light on how cells malfunction.
For pathologists and clinical laboratory managers, these new research findings hold the promise to open up another approach to using the data in whole human genomes for diagnostic and therapeutic purposes. It also shows one more practical outcome from the rapidly falling cost of sequencing DNA. (more…)
Feb 8, 2013 | Digital Pathology, Instruments & Equipment, Laboratory Instruments & Laboratory Equipment, Laboratory Management and Operations, Laboratory News, Laboratory Operations, Laboratory Pathology
Pathologists and clinical laboratory managers should fundamentally change how cancer specimens are handled
Three physicians at Scripps Health are calling for pathologists to rethink how they collect and store cancer tissue samples in two significant ways. They say that pathologists need to: 1) move away from formalin-fixed, paraffin-embedded (FFPE) tissue blocks and toward frozen samples; and, 2) start collecting larger samples.
These doctors used the Journal of the American Medical Association as a platform to issue their call for a change in what has been a long-standing standard of practice in anatomic pathology. Given the progressive nature of these opinions, there will certainly be dissenting voices within the pathology profession who are likely to add their voices to this debate.
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