Sep 22, 2014 | Coding, Billing, and Collections, Digital Pathology, Laboratory Management and Operations, Laboratory News, Laboratory Operations, Laboratory Pathology
More than 12 cancer types were studied in this project, which is a part of The Cancer Genome Atlas
New molecular and genetic knowledge is making it possible for researchers to propose a new system for classifying tumors. Upon implementation, such a system will give oncologists and pathologists, and clinical laboratory professionals a new tool to improve how they diagnose and treat cancer patients.
Tumor categories—defined by cell types instead of where they are found in the body—may lead to more accurate diagnoses and more effective treatments for one in 10 patients, according to the recent study. It was summarized in a Medline Plus Health News By Date story posted on the National Institutes of Health (NIH) website. (more…)
Aug 22, 2014 | Digital Pathology, Instruments & Equipment, Laboratory Instruments & Laboratory Equipment, Laboratory News, Laboratory Operations, Laboratory Pathology, Laboratory Testing
The four exome test kits examined as part of this study failed to deliver quality results, particularly because they often missed some disease-causing mutations altogether
Human exome sequencing is gaining favor among medical laboratories wanting to use this information for clinical purposes. However, the accuracy of some exome-capture test kits available on the market today has come under question.
A team from the Thomas Jefferson University in Philadelphia surveyed the potential false-negative rate of mutations in 56 disease-causing genes produced by four different commercially available human exome-capture test kits. The researchers found that these test kits failed to deliver quality results, sometimes missing mutations altogether, noted a report published by Medical Daily. (more…)
Jul 7, 2014 | Digital Pathology, Laboratory Operations, Laboratory Pathology, Management & Operations
This investigation of the fruit fly’s transcriptome—the complete collection of the genome’s RNA—unearthed thousands of new genes, transcripts, and proteins
Scientists have teased another level of information out of the genome. This time, the new insights were developed from studies of the fruit fly’s transcriptome. This knowledge will give pathologists another channel of information that may be useful in developing assays to support more precise diagnosis and therapeutic decisions.
The findings were published in a recent issue of Nature. The study focused on the transcriptome—a complete collection of the genome’s RNA—of the common fruit fly−Drosophila melangogaster. (more…)
Apr 25, 2014 | Digital Pathology, Instruments & Equipment, Laboratory Management and Operations, Laboratory Operations, Laboratory Pathology
The discovery of dual-purpose condons, called ‘duons’ opens the door to creation of more precise diagnostic and medical laboratory tests, as well as better treatment choices
New insights into the human genome have led to the discovery of a second “code” or “language” within human DNA. Pathologists performing genetic testing will be particularly interested in the implications of this discovery, which the researchers have dubbed “duons.”
It was a research team at the University of Washington (UW) that discovered evidence of a second type of DNA code overlying the protein code that controls transcription factors (TFs). TFs regulate flow of genetic information from DNA to messenger RNA, which manages the synthesis of proteins described by the DNA. (more…)
Apr 7, 2014 | Laboratory Management and Operations, Laboratory News, Laboratory Operations, Laboratory Pathology, Management & Operations, News From Dark Daily
Variability in how tissue is handled from one histopathology laboratory to another greatly affects quality of specimen and accuracy of the pathologist’s diagnosis
TORONTO, ONTARIO, CANADA—Here on the shores of Lake Ontario, pathologists and clinical laboratory professionals gathered last week for a unique conference that focused on quality issues involving how tissue is handled from collection and transport to the histopathology laboratory processing to diagnosis by surgical pathologists.
Your Dark Daily editor was here to participate in the conference and learn from a first-rank panel of speakers. As many long-time readers know, patients, physicians, and health insurers expect increasingly higher levels of accuracy in how lab specimens are handled and greater precision in the resulting diagnosis that is produced by pathologists. Thus, a conference dedicated to tissue specimen integrity and quality is both timely and appropriate. (more…)
